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EBI is a complex and multifactorial process involving reduced cerebral blood flow, BBB disruption, lipid peroxidation and other pathological events

Early detection enables individuals to plan for future care needs

A distinctive feature of the WD is the excessive consumption of both ultra-processed and fast-foods, rich in unhealthy components typical of the WD, such as saturated fats and refined carbohydrates, but poor in healthy nutrients, such as vitamins, fibers, and trace elements

Meanwhile, HK2 interacts with the mitochondrial membrane protein VDAC, disrupting mitochondrial membrane potential and promoting succinic acid accumulation and mtROS burst (126128)